THE HER2-DIRECTED ANTIBODY-DRUG CONJUGATE DHES0815A IN ADVANCED AND/OR METASTATIC BREAST CANCER: PRECLINICAL CHARACTERIZATION AND PHASE 1 TRIAL RESULTS

iphone 14 price miami Abstract Approved antibody-drug conjugates (ADCs) for HER2-positive breast cancer include trastuzumab emtansine and trastuzumab deruxtecan.To develop a differentiated HER2 ADC, we chose an antibody that does not compete with trastuzumab or pertuzumab for binding, conjugated to a reduced potency PBD (pyrrolobenzodiazepine) dime

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Abstract With the globalization of occupational health psychology, more and more researchers are interested in applying employee well-being like work engagement (i.e., a positive, fulfilling, work-related state of mind that is characterized by vigor, dedication, and absorption) to diverse populations.Accurate measurement contributes to our further

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